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V.A.C.® Therapy Healing Outcomes

Consider V.A.C. Therapy: A Solution Associated with Positive Healing Outcomes

Data from multiple randomized controlled trials (RCTs) have shown that in many healing categories, V.A.C. Therapy has consistently demonstrated positive diabetic foot wound healing outcomes compared to AMWT*.

More Patients With Complete (100%) Closure
Shorter Time to 76-100% Granulation Tissue Formation
Greater Wound Depth and Volume Reduction
Greater Wound Area Reduction
Shorter Time to Complete Wound Closure

More Patients with Complete (100%) Wound Closure4

More Patients with Complete Wound Closure
Complete closure = 100% re-epithelialization without drainage.
  • In the Blume 2008 RCT, V.A.C. Therapy patients who completed the 112-day active therapy phase had more wounds completely closed (V.A.C. Therapy 73/169, 60.8% vs. AMWT 48/166, 40%; p=0.001).4
  • In the Armstrong 2005 RCT, more V.A.C. Therapy patients (56%; 43/77) achieved complete wound closure than AMWT* patients (39%; 33/85), (p=0.040) at the end of the 112-day active treatment phase.2

*AMWT = Advanced Moist Wound Therapy (hydrogels, alginates, collagen and hydrocolloids).

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Shorter Time to 76-100% Granulation Tissue Formation2

Shorter Time to 76-100% Granulation Tissue Formation (days)
  • In the Armstrong 2005 RCT, more V.A.C. Therapy patients progressed from 0-10% granulation tissue at baseline to 76-100% granulation tissue formation in significantly less median time: V.A.C. Therapy (n=19), 42 days vs. AMWT, (n=15), 84 days, (p=0.002).2
  • In the Blume 2008 RCT, more V.A.C. Therapy patients progressed from 0-10% granulation tissue at baseline to 76-100% granulation in half the time: V.A.C. Therapy (n=24), 56 days vs. AMWT (n=22), 114 days (p = 0.022).4

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Greater Wound Depth and Volume Reduction11

Greater Wound Volume Reduction
  • In the Eginton RCT, 10 patients with 11 wounds were enrolled (n=10). A cross-over design was used with each wound being randomized to receive either moist dressings or V.A.C. Therapy for 2 weeks followed by the alternative dressing for 2 weeks. Analysis was based on six patients with seven wounds.
  • In this same RCT V.A.C. Therapy significantly decreased the depth 49% vs. 8% for moist wound dressings; (p<0.05), in a cross-over design over four weeks in six patients with seven wounds.
  • Eginton reported that V.A.C. Therapy significantly decreased the wound volume (59% vs. 0.1%; p<0.005) vs. moist wound dressings.

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Greater Wound Area Reduction16

Greater Wound Area Reduction
  • In the McCallon 2003 RCT, 10 patients with post-operative diabetic foot wounds were treated with either V.A.C. Therapy (n=5) or Saline Moistened Gauze (SMG) (n=5). V.A.C. Therapy wounds achieved a greater wound surface area change of 28.4% (average decrease in wound size) vs. 9.5% (average increase in size) for SMG patients.16
  • In the Blume 2008 RCT comparing V.A.C. Therapy to AMWT in the treatment of diabetic foot ulcers, reduction in wound areas* from baseline became significantly different on day 28 of the 112-day study of 335 patients. By Day 28 ulcer area* reduction from baseline was almost 2 times greater with V.A.C. Therapy than with AMWT (p=0.021).4
Greater Wound Area Reduction
*Foot ulcers Wagner stage 2 or 3 and larger than 2 cm2 after debridement.

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Shorter Time to Complete Wound Closure4,2,16

Shorter Time to Complete Closure (days)
  • The Blume 2008 RCT reported that Kaplan-Meier median time to complete diabetic foot ulcer closure was 96 days for V.A.C. Therapy vs. >112 days for AMWT* (p=0.001).4
  • The Armstrong 2005 RCT reported that partial diabetic foot amputation patients treated with V.A.C. Therapy experienced significantly shorter time to complete wound closure within the 112 active treatment period (Kaplan-Meier Estimates; p=0.005).2
  • Armstrong reported shorter median time to complete wound closure, V.A.C. Therapy 56 days vs. AMWT* 77 days, a difference of 21 days.2
  • McCallon, et al reported that V.A.C. Therapy patients achieved satisfactory healing in almost half the time compared to patients treated with Saline Moistened Gauze (SMG).16
    • Postoperative diabetic foot wounds treated with V.A.C. Therapy (22.8 days) had a shorter average time to satisfactory healing when compared to SMG (42.8 days).16
    • V.A.C. Therapy patients attained satisfactory healing via definitive closure approximately 3 weeks sooner than SMG patients.16

*The duration of the control treatment could not be estimated (Kaplan-Meier).

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